Palestinian and Israeli officials say that Israeli forces have killed five Palestinian men in four separate incidents in the occupied West Bank.
Three men, including two brothers in their 20s, were shot dead during overnight clashes with Israeli troops near Ramallah and Hebron.
Israel’s military said the fourth was shot after he rammed his car into a soldier, seriously injuring her.
The fifth reportedly died after fresh clashes near Ramallah in the evening.
The UN has warned that the Israeli-Palestinian conflict is “again reaching a boiling point” after the escalation of violence in the West Bank and Israel.
Israeli forces are carrying out search-and-arrest raids almost every night in the West Bank, where at least 140 Palestinians have been killed this year, most by Israeli fire. More than 30 Israelis have also been killed amid a spate of gun and knife attacks by Palestinians.
Jawad Rimawi, 22, and Thafer Rimawi, 21, students at Birzeit University, were killed early on Tuesday about 16km (10 miles) north-west of Ramallah.
Palestinian sources said the brothers had visited a relative in the village of Beit Rima as Israeli forces carried out an operation in the area.
As the forces withdrew, confrontations broke out with dozens of young Palestinians, who threw stones and petrol bombs, the sources added.
The Palestinian health ministry said the brothers were shot and taken to a local hospital, where they died.
The Israel Defense Forces (IDF) said that a “riot was instigated by a number of suspects” during a “routine” overnight activity.
“The suspects hurled rocks and Molotov cocktails toward the soldiers, who responded with riot dispersal means and live fire,” it added
Mufeed Ikhlil, a 44-year-old father of six, was shot in the head by Israeli troops during overnight clashes with stone-throwing Palestinians in Beit Ummar, about 10km north of Hebron, the Palestinian health ministry said. He died in hospital.
Eight other Palestinians were shot and injured, according to the ministry.
The IDF said two army jeeps got stuck in Beit Ummar due to “technical malfunctions” during a patrol.
It added that the troops in the vehicles were attacked by Palestinian “rioters” who “hurled rocks and improvised explosive devices at the soldiers”.
West Bank-based Palestinian Authority Prime Minister Mohammed Shtayyeh called the three killings an “ugly crime”. At the same time, the spokesman of President Mahmoud Abbas warned that “the daily killing of Palestinians is a declaration of war”.
A spokesman for the militant group Hamas, which controls the Gaza Strip, said Israel’s “escalation of its crimes and terrorism will be met with an escalation of resistance”.